02031nas a2200229 4500008004100000022002500041245011300066210006900179260001500248300001200263490000700275520130900282653002601591653002301617653001501640653002701655653001001682653001001692100003101702700002101733856004701754 2020 eng d a2211-3525, 2211-353300aAntimicrobial Activity of SPC13, New Antimicrobial Peptide Purified from Scolopendra polymorpha Venom0 aAntimicrobial Activity of SPC13 New Antimicrobial Peptide Purifi c11/09/2020 a233-2380 v183 a

Introduction: Currently animal venoms are considered a potential source of numerous bioactive peptides of biochemical and pharmacological interest, such as peptides with antithrombotic, anticoagulant and antimicrobial activity.

Methods: Such is the case of the venom from the genus Scolopendromorpha, where numerous PAMs ranging from 2.5 to 4.4 kDa have been purified, they are broad spectrum isolates only of S. subspinipes mutilans.

Results: In this study, an antimicrobial peptide (SPC13) of 13 kDa, present in the venom of Scolopendra polymorpha was purified by electroelution and presented antimicrobial activity against S. aureus and P. aeruginosa with MIC of 45 and 192.5 μg/ml respectively, as well as bacteriostatic activity against E. coli at a concentration of 155μg/ml.

Conclusion: Additionally, this peptide has a 20.5% hemolytic activity. A partial sequence of SPC13 showed 98% identity with the histone H3 reported in S. viridis (GenkBank: DQ222181.1).

Recommended citation: Rodríguez-Alejandro C.I. and Gutiérrez M.C. Antimicrobial Activity of SPC13, New Antimicrobial Peptide Purified from Scolopendra polymorpha Venom. Anti-Infective Agents, 18 (3): 233-238. https://doi.org/10.2174/2211352517666190531110829

10aAntimicrobial peptide10ahemolytic activity10aresistance10aScolopendra polymorpha10aSPC1310aVenom1 aRodríguez-Alejandro, C.I.1 aGutiérrez, M.C. uhttps://www.eurekaselect.com/article/98680