@article {832, title = {Gene content evolution in the arthropods}, journal = {Genome Biology}, volume = {21}, year = {2020}, month = {23/01/2020}, pages = {1-14}, abstract = {

Background: Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome. Dissection of the genomic record of sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods.
Results: Using 76 whole genome sequences representing 21 orders spanning more than 500 million years of arthropod evolution, we document changes in gene and protein domain content and provide temporal and phylogenetic context for interpreting these innovations. We identify many novel gene families that arose early in the evolution of arthropods and during the diversification of insects into modern orders. We reveal unexpected variation in patterns of DNA methylation across arthropods and examples of gene family and protein domain evolution coincident with the appearance of notable phenotypic and physiological adaptations such as flight, metamorphosis, sociality, and chemoperception.
Conclusions: These analyses demonstrate how large-scale comparative genomics can provide broad new insights into the genotype to phenotype map and generate testable hypotheses about the evolution of animal diversity.

}, keywords = {Arthropods, DNA methylation, Evolution, Gene content, Genome assembly, Genomics, Protein domains}, issn = {1474-760X}, doi = {10.1186/s13059-019-1925-7}, url = {https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1925-7}, author = {Thomas, Gregg W. C. and Dohmen, Elias and Hughes, Daniel S. T. and Murali, Shwetha C. and Poelchau, Monica and Glastad, Karl and Anstead, Clare A. and Ayoub, Nadia A. and Batterham, Phillip and Bellair, Michelle and Binford, Greta J. and Chao, Hsu and Chen, Yolanda H. and Childers, Christopher and Dinh, Huyen and Doddapaneni, Harsha Vardhan and Duan, Jian J. and Dugan, Shannon and Esposito, Lauren A. and Friedrich, Markus and Garb, Jessica and Gasser, Robin B. and Goodisman, Michael A. D. and Gundersen-Rindal, Dawn E. and Han, Yi and Handler, Alfred M. and Hatakeyama, Masatsugu and Hering, Lars and Hunter, Wayne B. and Ioannidis, Panagiotis and Jayaseelan, Joy C. and Kalra, Divya and Khila, Abderrahman and Korhonen, Pasi K. and Lee, Carol Eunmi and Lee, Sandra L. and Li, Yiyuan and Lindsey, Amelia R. I. and Mayer, Georg and McGregor, Alistair P. and McKenna, Duane D. and Misof, Bernhard and Munidasa, Mala and Munoz-Torres, Monica and Muzny, Donna M. and Niehuis, Oliver and Osuji-Lacy, Nkechinyere and Palli, Subba R. and Panfilio, Kristen A. and Pechmann, Matthias and Perry, Trent and Peters, Ralph S. and Poynton, Helen C. and Prpic, Nikola-Michael and Qu, Jiaxin and Rotenberg, Dorith and Schal, Coby and Schoville, Sean D. and Scully, Erin D. and Skinner, Evette and Sloan, Daniel B. and Stouthamer, Richard and Strand, Michael R. and Szucsich, Nikolaus U. and Wijeratne, Asela and Young, Neil D. and Zattara, Eduardo E. and Benoit, Joshua B. and Zdobnov, Evgeny M. and Pfrender, Michael E. and Hackett, Kevin J. and Werren, John H. and Worley, Kim C. and Gibbs, Richard A. and Chipman, Ariel D. and Waterhouse, Robert M. and Bornberg-Bauer, Erich and Hahn, Matthew W. and Richards, Stephen} }